ABSTRACT


Background: Papaya (Carica papaya L.) is a traditional medicinal plant, which has many health benefits. Phytochemical analysis showed that papaya leaf extract contains alkaloids, saponins have antibacterial properties. Shigella sp is the leading cause bacillary dysentery bacteria. Bacillary dysentery is a disease characterized by severe abdominal pain, diarrhea, often with little volume of stool, with mucus and blood.
Methods: pure Experimental Laboratory (true experiment) with a simple experimental design (with unique design group posttest control). The extraction method used is the method maserasi.Pengujian antibacterial activity using the agar diffusion method (method of wells) with extract concentrations of 20%, 15%, 10%, and ciprofloxaxin as a positive control and as Na-CMC a negative control. Each treatment was repeated six times.
Results: Papaya leaf extract can inhibit the growth of bacteria Shigella dysenteria at a concentration of 20%, 15%, 10%, with the result row is 17.02 mm, 10.01 mm and 6.02 mm. Minimum inhibitory concentration (MIC) at a concentration of 10% (6.02 mm). Test results using a statistical significance value way ANOVA p