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  <title>EFEK ANTIBAKTERI EKSTRAK&#13;
DAUN ROVIGA (Calotropis gigantea) TERHADAP&#13;
PERTUMBUHAN BAKTERI&#13;
Escherichia coli</title>
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  <namePart>ANNISA PRISCASARI DWIYANTI BAHRUDIN N 101 13 065</namePart>
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   <publisher>PSPD</publisher>
   <dateIssued>2017</dateIssued>
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  <languageTerm type="code">id</languageTerm>
  <languageTerm type="text">Indonesia</languageTerm>
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  <form authority="gmd">Skripsi Kedokteran</form>
  <extent>xvi ,44 hlm ; 29 cm</extent>
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 <note>xv&#13;
ABSTRAK&#13;
Latar Belakang: Escherichia coli (E. coli) adalah bakteri gram negatif dan bersifat heterotrof yang menyebabkan beberapa kasus seperti diare. Manifestasi klinik infeksi oleh Escherichia coli bergantung pada lokasi infeksi yang terjadi. Salah satu tanaman daun yang berpotensi menjadi obat untuk masyarakat adalah daun roviga (Calotropis gigantea) karena daun roviga mengandung flavonoid dan tanin yang memiliki efek sebagai antibakteri. Hal ini yang mendasari penulis melakukan penelitian tentang efek antibakteri ekstrak daun roviga (Calotropis gigantea) terhadap pertumbuhan bakteri Escherichia coli.&#13;
Tujuan: Untuk mengetahui efek antibakteri ekstrak daun roviga terhadap pertumbuhan bakteri Escherichia coli.&#13;
Metode: Penelitian ini termasuk jenis penelitian eksperimental laboratorium post-test only control group, dimana peneliti melakukan pengamatan terhadap kelompok kontrol dan kelompok perlakuan setelah diberikan intervensi. Data yang diperoleh selanjutnya dianalisa dengan uji One Way ANOVA dan Post Hoc Test Duncan.&#13;
Hasil: Diameter zona hambat paling besar diperoleh pada kontrol positif, yaitu dengan rerata 36.5 mm dan diikuti pada perlakuan 80% (12.8), 40% (10.4), sedangkan konsentrasi 10%, 20% dan kontrol negatif yang digunakan menunjukkan tidak adanya hambatan terhadap masing-masing replikasi. Berdasarkan analisis statistik uji post hoc, konsentrasi ekstrak daun roviga (Calotropis gigantea) yang paling efektif untuk menghambat pertumbuhan bakteri Escherichia coli adalah konsentrasi 80%.&#13;
Kesimpulan: Pada eksperimen ekstrak daun roviga (Calotropis gigantea) menunjukkan bahwa dengan meningkatkan konsentrasi ekstrak, maka semakin besar efek antibakteri ekstrak daun roviga dalam menghambat pertumbuhan koloni bakteri Escherichia coli.&#13;
Kata Kunci: Ekstrak daun roviga, Calotropis gigantea, Antibakteri, Escherichia coli&#13;
xvi&#13;
ABSTRACT&#13;
Background: Escherichia coli (E. coli) bacteria are gram-negative heterotrophic nature and cause some cases such as diarrhea. Clinical manifestations of infection by Escherichia coli depending on the location of the infection occurs. One of the plant leaf could potentially be a remedy to the community is the leaf roviga (Calotropis gigantea) because roviga leaves contain flavonoids and tannins which have effect as antibacterial. This is the underlying writer doing research on the antibacterial effect of the extract of leaves roviga (Calotropis gigantea) against the growth of bacteria Escherichia coli.&#13;
Objectives: To identify the antibacterial effect of roviga leaves extract (Calotropis gigantea) on the growth of Escherichia coli. Methods: This research includes laboratory experimental research type post test only control group, in which researchers conduct observations on the control group and treatment group after being given the intervention. Further data obtained were analyzed with ANOVA test One Way and Post Hoc Duncan Test. Results: Inhibition diameter zone most of the positive control obtained at, with average 36.5 mm and followed in the treatment of 80% (12.8), 40% (10.4), whereas the concentration of 10%, 20% and the negative control indicates the absence of barriers used against each replication. Based on a statistical analysis of the post hoc tests, the concentration of extract leaves roviga (Calotropis gigantea) are most effective for inhibiting the growth of the bacterium Escherichia coli is a concentration of 80%. Conclusion: The experiment of roviga leaf extract (Calotropis gigantea) shows by increasing the concentration of extracts, then the greater antibacterial effects of extracts of leaves roviga in inhibiting the growth of colonies bacteria Escherichia coli.&#13;
Keywords: Roviga Leaves Extract, Calotropis gigantea, Antibacteria, Escherichia coli</note>
 <note type="statement of responsibility">ANNISA PRISCASARI DWIYANTI BAHRUDIN N 101 13 065</note>
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  <topic>JAMU</topic>
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